General anesthesiology

Review: avoid severe hypotension, but trials do not show higher blood pressure targets protect the kidneys

This narrative review finds a consistent, roughly dose-response association between intraoperative hypotension (especially MAP below 60-65 mmHg) and postoperative AKI in observational studies. Randomized trials of individualized or higher blood pressure targets have generally not confirmed kidney protection, and IOH definitions vary widely.

Why it matters. Explains why current evidence supports avoiding severe, sustained hypotension without endorsing higher targets for renal protection.

Limitation. Narrative review; the authors describe their conclusion as provisional.

Remimazolam vs Propofol for Motor and Somatosensory Evoked Potentials in Spinal Tumor Surgery

Phase 4 trial planning 190 participants, sponsored by Beijing Tsinghua Chang Gung Hospital. Status: not yet recruiting. Conditions: Spinal Cord Neoplasms, Spinal Neoplasms.

Effects of Ciprofol on Perioperative Neurocognitive Function in Elderly Patients Undergoing Daytime Surgery

Phase 4 trial planning 148 participants, sponsored by Second Affiliated Hospital of Wenzhou Medical University. Status: enrolling by invitation. Conditions: PND, POCD - Postoperative Cognitive Dysfunction.

Effect of Neuromuscular Blocking Agent Use on Video Laryngeal Mask Airway Insertion

Phase 4 trial planning 128 participants, sponsored by Hacettepe University. Status: not yet recruiting. Conditions: Airway Management, Laryngeal Mask Airways, Neuromuscular Blockade.

Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean Section

Phase 4 trial planning 96 participants, sponsored by Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital. Status: completed. Conditions: Hypotension, Spinal Anesthesia, Cesarean Section.

Sevoflurane Versus Propofol Anesthesia in Intracardiac Echocardiography-Guided Atrial Fibrillation Ablation

Phase 4 trial planning 124 participants, sponsored by Hüseyin Ulaş Pinar. Status: not yet recruiting. Conditions: Persistent Atrial Fibrillation.

Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department.

Phase 4 trial planning 100 participants, sponsored by Sultan Qaboos University. Status: not yet recruiting. Conditions: Procedural Sedation.

Evaluation of the Efficacy of Intravenous Lidocaine on Chronic Post-operative Pain in Patients Requiring Emergency Abdominal Surgery

Phase 3 trial planning 266 participants, sponsored by Nantes University Hospital. Status: not yet recruiting. Conditions: Chronic Pain.

Suzetrigine for Analgesia in Arthroscopic Rotator Cuff Repair

Phase 4 trial planning 100 participants, sponsored by University of Alabama at Birmingham. Status: not yet recruiting. Conditions: Pain After Shoulder Surgery, Opioid Consumption, Postoperative.

Suzetrigine in TKA

Phase 3 trial planning 148 participants, sponsored by Hospital for Special Surgery, New York. Status: recruiting. Conditions: Total Knee Arthroplasty (TKA), Pain Management.