Clinical trials

Practice-shaping trials to watch and new phase 2–4 trials in anesthesia, pain and critical care. Synced from ClinicalTrials.gov; last checked 2026-10-28.

Trial watchlist

16 trials

Cardiac & perioperative

B-FreeActive not recruiting
Benzodiazepine-free cardiac anesthesia and delirium
Not phased · n=15,886 · primary completion 2022-12-11 · Population Health Research Institute

Regional & acute pain

NaV1.8 blocker for knee arthroplasty analgesia
Phase 3 · n=148 · Hospital for Special Surgery, New York
NaV1.8 blocker after arthroscopic shoulder surgery
Phase 4 · n=100 · University of Alabama at Birmingham
ENDPAINNot yet recruiting
Perioperative esketamine for endometriosis surgery pain
Phase 4 · n=1,000 · Region Skane
IV lidocaine to prevent chronic postoperative pain
Phase 3 · n=266 · Nantes University Hospital

Critical care

REMAP-CAPRecruiting
Adaptive platform trial in severe community-acquired pneumonia
Phase 3 · n=20,000 · primary completion 2026-02 · UMC Utrecht
ARISE FLUIDSActive not recruiting
Restricted fluids with early vasopressors in ED sepsis
Phase 3 · n=1,000 · primary completion 2026-02-01 · Australian and New Zealand Intensive Care Research Centre

Completed landmarks

REGAINCompleted
Spinal vs general anesthesia for hip fracture surgery
Not phased · n=1,848 · primary completion 2021-06 · University of Pennsylvania
POISE-3Completed
Tranexamic acid and hypotension-avoidance in noncardiac surgery
Phase 3 · n=9,535 · primary completion 2021-11-08 · Population Health Research Institute
POISE-2Completed
Perioperative aspirin and clonidine
Phase 3 · n=10,010 · primary completion 2014-03 · Hamilton Health Sciences Corporation
PROTHORCompleted
High vs low PEEP during one-lung ventilation
Not phased · n=2,200 · primary completion 2024-08 · Technische Universität Dresden
DEVICECompleted
Video vs direct laryngoscopy for emergency intubation
Not phased · n=1,420 · primary completion 2022-11-17 · Vanderbilt University Medical Center
PREOXICompleted
Noninvasive ventilation vs oxygen mask for preoxygenation
Not phased · n=1,301 · primary completion 2023-10-14 · Vanderbilt University Medical Center
TRICS-IIICompleted
Restrictive vs liberal transfusion in cardiac surgery
Not phased · n=5,028 · primary completion 2017-04-28 · Unity Health Toronto
DECADECompleted
Dexmedetomidine after cardiac surgery
Phase 4 · n=798 · primary completion 2018-12 · The Cleveland Clinic
ENGAGESUnknown
EEG-guided anesthesia and postoperative delirium
Not phased · n=1,400 · primary completion 2018-05 · Washington University School of Medicine

New trials registered

Last 60 days

The watchlist is curated in config/watchlist.json; every NCT number is checked against the registry on each run.